Abstract #4376

Impact of Waist Circumference in Older Adults on Cerebral Oxygen Extraction Fraction

Suhaas Penukonda¹, Sri Srinivasan¹, Frank Yu², Hanzhang Lu³, Travis Sapp², Ihab Hajjar⁴, Laura Lacritz⁵, James de Lemos⁶, Amil Shah⁶, and Binu Thomas¹

¹Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ²Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, ³Department of Radiology, John Hopkins University, Baltimore, MD, United States, ⁴Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁵Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁶Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States

Synopsis

Keywords: Aging, Metabolism, Oxygen Extraction Fraction, Waist Circumference

Motivation: Alterations in cerebral oxygen extraction fraction (OEF) with age and obesity propose potential biomarkers for neurodegeneration.

Goal(s): We assess the influence of waist circumference (WC) on OEF across different age groups, evaluating the role of obesity in cerebral metabolism.

Approach: OEF was measured using TRUST-MRI, and cognition was evaluated in two groups (≥60 and <60 years) of 158 participants from the Dallas Heart and Minds study.

Results: In older adults, OEF decreased with increasing WC, indicating neurometabolic changes. In middle-age adults, OEF increased with WC, suggesting that obesity may accelerate age-related changes. OEF increased with age, and MoCA total scores decreased with age.

Impact: We report that oxygen extraction fraction (OEF) is increased in middle-age adults with obesity (<60 years), suggesting accelerated aging. Notably in adults older than 60 years, OEF decreased, indicating potential decrease in neuronal function.

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