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Abstract #4377

Investigation of the Relationship Between Electrical Conductivity, Diffusivity, and Tissue Volume in the Aging Brain

Geon-Ho Jahng1, Mun Bae Lee2, Hak Young Rhee3, Soonchan Park1, and Chang-Woo Ryu1
1Radiology, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of, 2Konkuk University, Seoul, Korea, Republic of, 3Neurology, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of

Synopsis

Keywords: Aging, Electromagnetic Tissue Properties, Conductivity

Motivation: This study provides novel insights into the intricate relationships between brain electrical conductivity, diffusivity, and tissue volume in elderly individuals.

Goal(s): To explore the relationships between electrical conductivity, diffusivity, and brain tissue volume in the aging brain.

Approach: With 77 patients, brain MREPT and DTI were employed to calculate high-frequency conductivity (HFC) and separate it into extra-neurite (EC) and intra-neurite (IC) conductivities.

Results: Multiple regression revealed a positive association of both HFC and EC with MD, RD, and axial diffusivity (AxD) in the hippocampus and insula. IC correlated positively with intra-neurite diffusivity (ID) in the amygdala, thalamus, and insula.

Impact: This research underscores the importance of distinguishing between conductivity and diffusion changes when interpreting clinical MREPT data.

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