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Abstract #4378

Quantitative assessment of iron and magnetic susceptibility in cortical regions of the same older adults

Rasheed Abid1, Md Tahmid Yasar1, Abdur Raquib Ridwan2, Mohammad Rakeen Niaz1, Yingjuan Wu2, Shengwei Zhang2, Ashley I. Bush3, Scott Ayton3, Arnold M. Evia2, David A. Bennett2, Julie A. Schneider2, and Konstantinos Arfanakis1,2
1Illinois Institute of Technology, Chicago, IL, United States, 2Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, United States, 3Florey Institute of Neuroscience and Mental Health, and The University of Melbourne, Parkville, Australia

Synopsis

Keywords: Aging, Alzheimer's Disease, Quantitative Susceptibility Mapping, Iron, Brain, Aging, Susceptibility, Autopsy

Motivation: Quantitative susceptibility mapping (QSM) is a promising in-vivo marker of iron levels in the brain. However, the relation of cortical magnetic susceptibility with iron in older adults remains uncertain, making it difficult to use in-vivo QSM to predict iron levels.

Goal(s): This study aims to establish the relationship between cortical magnetic susceptibility with iron in community-based older adults by addressing a number of limitations plaguing previous efforts.

Approach: This study in community-based older adults combined in-vivo QSM, inductively coupled plasma mass spectrometry at autopsy, and short antemortem intervals.

Results: Linear relationship between magnetic susceptibility and iron levels was established for older adult brain.

Impact: The present study established the relation of cortical magnetic susceptibility with iron levels in community-based older adults. This relationship may be used to estimate iron levels in-vivo based on QSM, thereby enhancing our understanding of iron dysregulation in neurodegenerative diseases.

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