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Abstract #4394

Advancing mesoscale whole brain T2*-weighted MRI in humans at 10.5 T using motion-robust multi-echo 3D EPI and RF parallel transmission

Shuxian Qu1, Jacco A. de Zwart2, Peter Van Gelderen2, Jeff H. Duyn2, Matt Waks1, Russell Lagore1, Alexander Bratch1, Andrea Grant1, Edward Auerbach1, Lance Delabarre1, Alireza Sadeghi Tarakameh1, Yigitcan Eryaman1, Gregor Adriany1, Kamil Ugurbil1, Xiaoping Wu1, and Jiaen Liu3,4
1CMRR, Radiology, Medical School, University of Minnesota, Minneapolis, MN, United States, 2Advanced MRI section, NINDS, NIH, Bethesda, MD, United States, 3Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 4Radiology, UT Southwestern Medical Center, Dallas, TX, United States

Synopsis

Keywords: High-Field MRI, High-Field MRI

Motivation: Last year we demonstrated at 10.5 T the utility of motion-robust multi-echo GRE imaging for mesoscale T2*-weighted (T2*w) whole brain MRI with 0.5-mm isotropic resolution.

Goal(s): To push the limit of mesoscale T2*w multi-echo whole brain MRI by combining motion-robust 3D EPI and parallel transmission (pTx).

Approach: Whole brain three-echo EPI at 0.4-mm isotropic resolution was performed using a custom 16-channel transmit 80-channel receive RF array with a scan time of ~10 min. Tailored pTx pulses were designed for uniform water excitation.

Results: Our new mesoscale image acquisition eliminated RF artifacts observed before, allowing intricate anatomical details to be visualized across the brain.

Impact: Armed with rapid motion-robust 3D EPI and parallel transmission, the presented new multi-echo T2*-weighted imaging strategy will benefit many neuroscience applications, especially those aiming to investigate fine scale anatomy in humans at ultrahigh field.

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Abstract

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