Abstract #4395

Advancing whole-brain BOLD fMRI in humans at 10.5 Tesla with motion-robust 3D EPI and RF parallel transmission: initial experience

Shuxian Qu¹, Peter Van Gelderen², Jacco A. de Zwart², Jeff H. Duyn², Matt Waks¹, Russell Lagore¹, Alexander Bratch¹, Andrea Grant¹, Edward Auerbach¹, Lance Delabarre¹, Alireza Sadeghi Tarakameh¹, Yigitcan Eryaman¹, Gregor Adriany¹, Kamil Ugurbil¹, Jiaen Liu^3,4, and Xiaoping Wu¹

¹CMRR, Radiology, Medical School, University of Minnesota, Minneapolis, MN, United States, ²Advanced MRI section, NINDS, NIH, Bethesda, MD, United States, ³Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, ⁴Radiology, UT Southwestern Medical Center, Dallas, TX, United States

Synopsis

Keywords: High-Field MRI, High-Field MRI

Motivation: Pursuing quality high resolution BOLD fMRI is a main driver for developing human MRI systems operated at > 10 Tesla (10T).

Goal(s): To promote whole-brain BOLD fMRI at 10.5T by combining parallel transmission (pTx), motion-robust 3D EPI, and high-density RF coil design.

Approach: Resting-state fMRI data were collected at 1.58-mm isotropic resolution using a custom 16-channel transmit, 80-channel receive RF array. Spatial spectral pTx pulses were designed to achieve uniform water excitation. Reconstruction was performed with vs. without navigator-based intra-volume motion and field correction.

Results: Corrected reconstruction effectively improved the quality of BOLD timeseries, reducing motion confounds and improving functional connectivity.

Impact: Demonstrated useful for whole-brain BOLD fMRI at 10.5 T, our pTx-enabled, motion-robust 3D EPI technique will have potential to advance ultrahigh resolution fMRI at ultrahigh field, paving the way for obtaining a better understanding of brain function and connectivity.

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