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Abstract #4398

In vivo Brain B1+ Inhomogeneity Correction and NOE Image Enhancement at 7T via Flexible Metasurfaces

Paul S. Jacobs1, Anshuman Swain1, Neil E. Wilson1, Wyger Brink2, Abeer Mathur1, Ravi Prakash Reddy Nanga1, Mark Elliott1, John Detre3, and Ravinder Reddy1
1Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Magnetic Detection and Imaging group, TechMed Centre, University of Twente, Enschede, Netherlands, 3Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: New Devices, CEST / APT / NOE, Metasurface, 7T

Motivation: NOE at 7 Tesla suffers from image degradation due to signal drop off caused by B1 inhomogeneity.

Goal(s): To demonstrate in vivo on 7T MRI, brain B1+, NOEMTR, and multipool metabolite map enhancement via metasurfaces.

Approach: 3D NOE images were acquired, consisting of a full Z-spectrum, which was used in conjunction with a multipool Lorentzian fitting model to generate MT, APT, amine, and rNOE pools. B1+ maps were acquired as an additional comparison metric.

Results: Metasurfaces globally enhanced the transmit efficiency, particularly in the temporal lobe regions. NOEMTR and amplitude fit maps showed improved image contrast and uniformity.

Impact: Metasurfaces improve metabolic NOE image quality at 7T, making this technique more suitable for investigating pathologies in the temporal lobes and cerebellum.

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Keywords