Meeting Banner
Abstract #4460

Field dependence of T2 relaxation due to diffusion through an inhomogeneous medium.

Peter van Gelderen1, Jacco de Zwart1, Yicun Wang2, and Jeff Duyn1
1Advanced MRI section, LFMI/NINDS, National Institutes of Health, Bethesda, MD, United States, 2Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, United States

Synopsis

Keywords: Relaxometry, Brain

Motivation: Brain iron in the form of ferritin is an important contributor to R2 relaxation. We aim to understand why this contribution was shown to be linear with field strength in our previous study (ISMRM2023:4342), contrary to the expected quadratic dependence.

Goal(s): To explain R2 (=1/T2) field dependence and the role of iron distribution in R2 relaxation.

Approach: Simulate effects on R2 from diffusion through field inhomogeneities from tissue iron.

Results: Simulations explain both the magnitude and field dependence of diffusion mediated R2 relaxation due to iron clustered at the spatial scale of cells. With increasing field, the dependence transitions from B02 to B00.66.

Impact: This study helps to explain a previously observed linear dependence of R2 relaxation on the field strength (ISMRM2023:4342) by simulating the effects of diffusion through the iron-induced field inhomogeneities.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords