Keywords: Relaxometry, biology, models, methods, Relaxometry
Motivation: Fast-field cycling (FFC) NMR provides biologically relevant information linked to proton dynamics at low fields. These dynamics lack understanding, so low-field T1 diagnostic capabilities are unclear.
Goal(s): Identify which dynamics are responsible for T1 relaxation dispersion and whether this provides accurate information, using a simple biological structure.
Approach: Investigate if FFC-NMR T1 measurements of purified blood clots can be explained using known mathematical expressions modelling molecular motions.
Results: The FFC-NMR T1 relaxation dispersion profiles of blood clots do conform to models in a specific frequency region. This can be used to accurately define the surface topology of fibrin fibres
Impact: Characterising biological information inferred by FFC-NMR relaxometry will simplify non-invasive exploration into how pathology influences molecular behaviour and provides insight into new applications.
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