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Abstract #4474

Elucidating Water Dynamics Driving T1 Relaxation in Biological Filamentous Structures below 200mT

Madeleine Rhodes1, NJ Mutch1, and Lionel M. Broche1
1Institute of Medical Science, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United Kingdom

Synopsis

Keywords: Relaxometry, biology, models, methods, Relaxometry

Motivation: Fast-field cycling (FFC) NMR provides biologically relevant information linked to proton dynamics at low fields. These dynamics lack understanding, so low-field T1 diagnostic capabilities are unclear.

Goal(s): Identify which dynamics are responsible for T1 relaxation dispersion and whether this provides accurate information, using a simple biological structure.

Approach: Investigate if FFC-NMR T1 measurements of purified blood clots can be explained using known mathematical expressions modelling molecular motions.

Results: The FFC-NMR T1 relaxation dispersion profiles of blood clots do conform to models in a specific frequency region. This can be used to accurately define the surface topology of fibrin fibres

Impact: Characterising biological information inferred by FFC-NMR relaxometry will simplify non-invasive exploration into how pathology influences molecular behaviour and provides insight into new applications.

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