Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non-Gas)
Motivation: Determine the optimal readout trajectory for metabolic imaging with hyperpolarised [1-13C]pyruvate in humans.
Goal(s): Implement and compare the two most common efficient spatial encoding schemes: spiral and EPI.
Approach: One metabolite in one slice is excited via a spectral-spatial pulse combined with a single-shot readout trajectory. For most comparable results, both spiral and EPI were alternated in a single sequence following one injection of hyperpolarised [1-13C]pyruvate.
Results: Spirals exhibit better SNR while EPI shows more image features, pointing to better spatial resolution.
Impact: 13C metabolic imaging provides valuable clinical information, such as tumour-treatment response, and may complement or provide an alternative to PET. For clinical studies, it is important to choose the optimal sequence.
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