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Abstract #4478

On The Optimal Readout Trajectory for Hyperpolarised 13C Metabolic Imaging

Rolf F Schulte1, Esben SS Hansen2, Jeremy Gordon3, Charles H Cunningham4,5, Albert P Chen6, Peder EZ Larson3, Maximillian Fuetterer7, Arnaud Comment8, and Christoffer Laustsen2
1GE HealthCare, Munich, Germany, 2Aarhus University, Aarhus, Denmark, 3University of California San Francisco, San Francisco, CA, United States, 4Sunnybrook Research Institute, Toronto, ON, Canada, 5University of Toronto, Toronto, ON, Canada, 6GE HealthCare, Taipei, Taiwan, 7ETH Zurich, Zurich, Switzerland, 8GE HealthCare, Cambridge, United Kingdom

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non-Gas)

Motivation: Determine the optimal readout trajectory for metabolic imaging with hyperpolarised [1-13C]pyruvate in humans.

Goal(s): Implement and compare the two most common efficient spatial encoding schemes: spiral and EPI.

Approach: One metabolite in one slice is excited via a spectral-spatial pulse combined with a single-shot readout trajectory. For most comparable results, both spiral and EPI were alternated in a single sequence following one injection of hyperpolarised [1-13C]pyruvate.

Results: Spirals exhibit better SNR while EPI shows more image features, pointing to better spatial resolution.

Impact: 13C metabolic imaging provides valuable clinical information, such as tumour-treatment response, and may complement or provide an alternative to PET. For clinical studies, it is important to choose the optimal sequence.

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