Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non-Gas)
Motivation: Rapid imaging methods with high temporal resolution and signal-to-noise ratio are required for hyperpolarized 13C-MRSI experiments.
Goal(s): Evaluation and optimization of the performance of CSI, MGE and me-bSSFP in a preclinical setting with respect to the requirements of hyperpolarization.
Approach: Construction of a phantom containing 13C-labeled reference solutions and SNR calculations for single metabolites in the reconstructed images acquired with optimized MRSI sequences.
Results: Successful separation of phantom metabolites indicates possible application of the optimized MRSI sequences in preclinical in-vivo studies.
Impact: The construction of a stable and reliable phantom with high homogeneity containing 13C-reference solutions enables standardized sequence optimization for hyperpolarized MRSI experiments. For preclinical in-vivo studies, single reference solutions can further be used for calibration measurements.
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