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Abstract #4479

Advancing 13C Metabolic MRSI: Enhanced Imaging Techniques and an effective standardized Phantom at 11.7 T

Julian Schüle1, Tobias Speidel1, Christoph A. Müller2, Sebastian Lucas2, and Volker Rasche1
1Ulm University Medical Center, Ulm, Germany, 2NVision Imaging Technologies GmbH, Ulm, Germany

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non-Gas)

Motivation: Rapid imaging methods with high temporal resolution and signal-to-noise ratio are required for hyperpolarized 13C-MRSI experiments.

Goal(s): Evaluation and optimization of the performance of CSI, MGE and me-bSSFP in a preclinical setting with respect to the requirements of hyperpolarization.

Approach: Construction of a phantom containing 13C-labeled reference solutions and SNR calculations for single metabolites in the reconstructed images acquired with optimized MRSI sequences.

Results: Successful separation of phantom metabolites indicates possible application of the optimized MRSI sequences in preclinical in-vivo studies.

Impact: The construction of a stable and reliable phantom with high homogeneity containing 13C-reference solutions enables standardized sequence optimization for hyperpolarized MRSI experiments. For preclinical in-vivo studies, single reference solutions can further be used for calibration measurements.

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