Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non-Gas), Carbon-13, Kinetic modelling, Metabolism
Motivation: Accurate interpretation of hyperpolarized (HP) 13C-MRI data is vital for advancing metabolic imaging techniques, yet existing models often overlook critical factors like transcapillary extraction.
Goal(s): This study aims to develop a comprehensive kinetic model that incorporates both perfusion and extraction, providing a more reliable assessment of metabolism in vivo.
Approach: We introduce a generalized model and validate it using in vivo HP 13C-MRI data from healthy volunteers, comparing parameter estimation to traditional ratio-metric analyses.
Results: Our model is able to quantify hemodynamics and metabolic rates across various scenarios and reveals that current approaches may misinterpret the contributions of metabolism and extraction.
Impact: Our generalized model potentially enables more accurate quantification of metabolism in HP 13C-MRI by accounting for perfusion and extraction effects. This advancement may support better interpretation of metabolic data, potentially leading to improved diagnostics and therapeutic monitoring in clinical settings.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords