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Abstract #4484

Kinetic Modeling of HP [1-13C]-Pyruvate Determines Dominant Physiological Parameters Influencing Lactate to Pyruvate AUC Ratio

Ryan Boyce1,2, Collin Harlan1, Qing Wang1, Christopher Walker1, Stephen Y Lai3, Matthew Merritt4, and James Bankson1
1Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX, United States, 2Department of Physics, University of Houston, Houston, TX, United States, 3Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, United States, 4Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL, United States

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Modelling

Motivation: The translation of HP [1-13C]-pyruvate as a method for quantifying aerobic glycolysis in tumors depends on a careful analysis of the processes that drive lactate production.

Goal(s): We seek to introduce a method to determine the rate-limiting steps in overall lactate production.

Approach: The HP pyruvate study of a patient with oropharyngeal squamous cell carcinoma was reanalyzed with pharmacokinetic modeling to determine relative levels of HP pyruvate in the three physical compartments of a pharmacokinetic model.

Results: Overall pyruvate signal was mostly dominated by extravascular/extracellular pyruvate, indicating that lactate production was not primarily influenced by intracellular metabolism.

Impact: The proposed analysis has the potential to aid in the analysis of [1-13C]-pyruvate studies by distinguishing between the effects of pyruvate delivery to the cells and true Warburg metabolism in tumors.

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Keywords