Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Gas), Spin dynamics
Motivation: To enhance hyperpolarization for MRI, focusing on cost-effective and broadly applicable parahydrogen-induced polarization relayed via proton exchange (PHIP-X).
Goal(s): To find optimal parameters in PHIP-X to maximize ¹³C and ¹⁵N polarization levels.
Approach: Our approach was to simulate quantum spin dynamics to study the effects of exchange rates, magnetic field cycling, proton relaxation and J-coupling networks.
Results: Optimal conditions are exchange rate of 200 s⁻¹, magnetic fields below 10 nT, labile proton relaxation times above 0.1 s and matching of J-couplings of labile protons. Polarizations up to 24% for ¹³C and 14% for ¹⁵N were found.
Impact: The findings pave the way to develop a pH2-based method that can strongly polarize 13C and 15N nuclei of a wide range of biomolecules playing an important role in metabolic MR imaging. Scientists may try to use new imaging agents.
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