Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non-Gas), metabolic imaging
Motivation: To provide a commercially available hyperpolarizer producing hyperpolarized agents rapidly and reliably, to enable large scale metabolic imaging studies.
Goal(s): To assess the reproducibility and polarization levels of the 13C-labeled 𝛂-ketoacids pyruvate and 𝛂-ketoglutarate achieved by POLARIS, a commercially available preclinical PHIP-based hyperpolarizer.
Approach: POLARIS produced injectable doses of hyperpolarized 13C-labeled pyruvate and 𝛂-ketoglutarate in 90 seconds. Polarization and reproducibility were assessed, and in vivo hyperpolarized imaging data acquired.
Results: Polarization of >30% for pyruvate and >25% for 𝛂-ketoglutarate were achieved reproducibly. In vivo images demonstrate biodistribution of 𝛂-ketoglutarate and metabolism of pyruvate in the healthy mouse brain.
Impact: POLARIS enables rapid, reproducible and high polarization of 13C-labeled 𝛂-ketoacids with an easy-to-use, highly automated workflow. This breakthrough enables fast, reproducible results, paving the way for extensive, consistent studies that will significantly advance the field of hyperpolarized MRI.
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