Meeting Banner
Abstract #4490

Fast PHIP-based hyperpolarization of 13C 𝛂-ketoacids using POLARIS: high polarization, reproducibility, and in vivo results

Myriam M Chaumeil1,2,3, Luca Nagel4, Zumrud Ahmadova1, Martin Gierse1, Martin Grashei4, Jonas Handwerker1, Felix Josten1, Senay Karaali1, Catriona Rooney1, Pascal Ruetten1, Pascal Wolff1, Ilai Schwartz1, Franz Schilling4, and Stephan Knecht1
1NVision Imaging Technologies, Ulm, Germany, 2Physics, Ulm University, Ulm, Germany, 3Physical Therapy and Rehabilitation Science, UCSF, San Francisco, CA, United States, 4Department of Nuclear Medicine, TUM School of Medicine and Health, TUM University Hospital, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non-Gas), metabolic imaging

Motivation: To provide a commercially available hyperpolarizer producing hyperpolarized agents rapidly and reliably, to enable large scale metabolic imaging studies.

Goal(s): To assess the reproducibility and polarization levels of the 13C-labeled 𝛂-ketoacids pyruvate and 𝛂-ketoglutarate achieved by POLARIS, a commercially available preclinical PHIP-based hyperpolarizer.

Approach: POLARIS produced injectable doses of hyperpolarized 13C-labeled pyruvate and 𝛂-ketoglutarate in 90 seconds. Polarization and reproducibility were assessed, and in vivo hyperpolarized imaging data acquired.

Results: Polarization of >30% for pyruvate and >25% for 𝛂-ketoglutarate were achieved reproducibly. In vivo images demonstrate biodistribution of 𝛂-ketoglutarate and metabolism of pyruvate in the healthy mouse brain.

Impact: POLARIS enables rapid, reproducible and high polarization of 13C-labeled 𝛂-ketoacids with an easy-to-use, highly automated workflow. This breakthrough enables fast, reproducible results, paving the way for extensive, consistent studies that will significantly advance the field of hyperpolarized MRI.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords