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Abstract #4491

Investigating the Mechanism of Inositol Against Paclitaxel Chemoresistance on TNBC by Using 7T Multiparametric MRI and Mitochondrial Changes

Wentao Xuan1, Wangmin Li1, Lixin Ke1, Yuanyu Shen1, Xiaolei Zhang1, Yue Chen1, Zhiliang Ye1, Caiyu Zhuang1, Shiyan Xie1, Renhua Wu1, and Yan Lin1
1The Second Affiliated Hospital of Shantou University Medical College, Shantou, China

Synopsis

Keywords: DWI/DTI/DKI, Cancer, Triple-negative breast cancer, Paclitaxel resistance, Mitochondrial dynamics, Inositol, Multiparametric MRI

Motivation: Paclitaxel resistance poses a challenge in treating triple-negative breast cancer (TNBC), necessitating new strategies to enhance treatment efficacy.

Goal(s): The study aims to explore whether inositol can inhibit PTX chemoresistance in TNBC by suppressing mitochondrial fission.

Approach: PTX-resistant 4T1 cells were inoculated in mice, which received treatments with PTX and/or inositol. Multiparametric MRI, histopathology, and biochemical analyses were used to assess effects on mitochondrial morphology and treatment outcomes.

Results: Inositol increased mitochondrial stability, reduced tumor volume, and lowered PTX resistance markers, demonstrating its potential to counteract PTX resistance in TNBC effectively.

Impact: The findings suggest that inositol could become a novel therapeutic strategy for overcoming PTX resistance in TNBC, potentially guiding future research on mitochondrial-targeted treatments. This could lead to improved clinical outcomes for patients with drug-resistant breast cancer.

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