Keywords: Muscle, Muscle
Motivation: It is unclear whether micro-dystrophin gene therapy will improve the metabolic status of dystrophic muscle.
Goal(s): The goal of this study is to understand the effects of micro-dystrophin gene therapy on skeletal muscle energetics in dystrophic muscle.
Approach: We used 31P-MRS to evaluate energetics and acid-base status in dystrophic mice and boys with Duchenne muscular dystrophy.
Results: We observed improved energetics and acid-base status after micro-dystrophin gene therapy in dystrophic mice and boys with Duchenne muscular dystrophy.
Impact: Overall, these findings support that 31P-MRS may be a valuable tool for evaluating treatments in muscular dystrophies.
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