Keywords: Muscle, Metabolism, MSK, Downfield
Motivation: Most previous downfield ¹H MRS studies have focused on brain metabolites, with relatively few investigations conducted on skeletal muscle.
Goal(s): To characterize the downfield metabolites in human skeletal muscle in vivo at 3T.
Approach: An optimized metabolite-cycled (MC)-sLASER was used to simultaneously measure the metabolites in the upfield and downfield regions of the skeletal muscle ¹H spectra.
Results: We detected three new peaks at ~10.1, 11.3, 11.7 ppm in the downfield region of the ¹H MRS of skeletal muscle at 3T that were not reported previously alongside the common upfield/downfield metabolites such as carnosine, IMCL/EMCL, creatine, TMA.
Impact: This is the first reported detection of new resonances at ~10.1, 11.3, and 11.7ppm in downfield of the ¹H MRS of skeletal muscle at 3T. This will be beneficial to study role of these metabolites in healthy and disease condition.
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