Keywords: Parkinson's Disease, Parkinson's Disease, Neuromelanin, synucleinopathies, Pure Autonomic Failure, phenoconversion
Motivation: Pure autonomic failure (PAF), a peripheral synucleinopathy, is associated with a high risk of progressing to central synucleinopathies, highlighting the need for early detection.
Goal(s): To assess neuromelanin-sensitive MRI contrast in the substantia nigra (SN) and locus coeruleus (LC) of PAF patients to identify early neurodegenerative changes.
Approach: PAF patients were divided into high-risk and low-risk groups, and we compared contrast ratios in the SN and LC among these groups and healthy controls.
Results: High-risk PAF patients exhibited significantly lower contrast ratios in the SN and LC compared to controls, indicating early neurodegenerative changes.
Impact: This study highlights the potential of neuromelanin-sensitive MRI as an early biomarker for neurodegenerative changes in high-risk PAF patients, aiding in the timely detection and intervention for central synucleinopathies, such as Parkinson disease.
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