Abstract #4524

Deciphering Blood-Brain Barrier Integrity in Parkinson’s Disease: A VEXI MRI Investigation

Yu Shen¹, Kaiyue Ding², Yan Bai¹, Zhaoqing Li³, Yifan Zhang⁴, Dingsheng Shi⁴, Yao Ge¹, Xianchang Zhang⁵, Ruiliang Bai⁶, and Meiyun Wang^1,7

¹Department of Radiology, Zhengzhou University People's Hospital & Henan Provincial People's Hospital, Zhengzhou, China, ²Department of Radiology, Henan Provincial People's Hospital & the People's Hospital of Henan University, Zhengzhou, China, ³Department of Physical Medicine and Rehabilitation, Affiliated Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China, ⁴Key Laboratory of Biomedical Engineering of Education Ministry, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, ⁵MR Research Collaboration, Siemens Healthineers Ltd, Zhengzhou, China, ⁶Interdisciplinary Institute of Neuroscience and Technology, Zhejiang University School of Medicine, Zhengzhou, China, ⁷Biomedical Research Institute, Henan Academy of Sciences, Zhengzhou, China

Synopsis

Keywords: Parkinson's Disease, Parkinson's Disease, Blood-brain barrier

Motivation: Blood-brain barrier (BBB) disruption has been observed in Parkinson’s disease (PD) pathology and is considered to contribute to disease progression. However, current imaging techniques for assessing BBB integrity, such as PET and DCE, rely on contrast agents, limiting their clinical utility.

Goal(s): To utilize the non-invasive vascular water exchange (VEXI) technique to assess BBB alterations in PD and investigate region-specific BBB changes related to disease severity.

Approach: We used VEXI MRI on 55 PD patients and 39 controls, analyzing apparent water exchange (AXR) rate in PD-related brain regions.

Results: Elevated AXR values were observed in PD-related brain regions, correlating with clinical severity.

Impact: This study positions VEXI MRI as a valuable tool for non-invasively mapping regional BBB changes in PD, enhancing understanding BBB alterations related BBB and supporting the more precise disease monitoring and intervention.

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