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Abstract #4527

Altered Brain Glymphatic System Impairment in Early Parkinson’s Disease and Atypical Parkinsonism

Yufan Chen1, Yang Zhao1, Mengyuan Zhuo2, Xiuzheng Yue3, and Guangbin Wang1
1Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, 2Shandong University, Jinan, China, 3Philips Healthcare, Beijiing, China

Synopsis

Keywords: Parkinson's Disease, Neurodegeneration

Motivation: Parkinsonism neurodegeneration is driven by diverse proteinopathies. The brain glymphatic system associates with neurodegenerative disorders characterized by neurotoxic protein aggregation.

Goal(s): To find more neuroimaging biomarkers and assist the target treatment of parkinsonism.

Approach: We calculated ChP volume, ratio and ALPS index to reflect the brain glymphatic function to grasp the change of brain glymphatic function in early PD, PSP and MSA.

Results: The ALPS was lowest in PSP while ChP showed a greater dispersion. When combining PD and MSA groups into α-synucleinopathies group and regarding PSP as tauopathy group, ALPS in tauopathy group was higher with an increasing ChP volume and ratio.

Impact: Impaired glymphatic function might be a pathophysiology marker of neurodegeneration disorders. Although the dispersion of ChP implies that this may not be a stabilizing factor, impaired glymphatic hydrodynamic function also support for glymphatic dysfunction in the proteopathy of parkinsonism.

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