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Abstract #4528

Macroscale Thalamus Functional Organization Disturbances and its Underlying genetic architecture in Parkinson’s disease motor subtypes

Shuting Bu1, Huize Pang1, Xiaolu Li1, Mengwan Zhao1, Juzhou Wang1, Yueluan Jiang2, and Guoguang Fan1
1the First hospital of China Medical University, Shenyang,Liaoning, China, 2MR Research Collaboration, Siemens Healthineers, Beijing China, Beijing, China

Synopsis

Keywords: Parkinson's Disease, Functional Connectivity

Motivation: Aim to explore the patterns of functional architecture of thalamus in different Parkinson's disease motor subtypes.

Goal(s): To construct functional architecture of thalamus in Parkinson's disease motor subtypes, compare the alterations between groups to explore the gradient patterns of thalamus and its associated genes.

Approach: This study compared the first two gradient alterations of thalamus among Parkinson's disease motor subtypes and healthy controls.

Results: The PIGD (postural instability and gait difficulty) subtype showed a contracted thalamus gradient while the TD (tremor-dominant) subtype exhibited an expanded gradient.

Impact: This study explored the functional architecture patterns of thalamus in different Parkinson's disease motor subtypes, and further explored the genes associated with thalamic gradient alterations.

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Keywords