Keywords: Parkinson's Disease, Diffusion Acquisition, DTI-ALPS
Motivation: The pathophysiological mechanisms underlying Parkinson's disease with depression (PDD) remain unclear.
Goal(s): To investigate the differences in lymphocyte function and BNST-cortex circuit functional connectivity(FC) across three groups: PDD, PDND and HC.
Approach: DTI-ALPS metrics and seed-based FC were extracted and statistical analysis was performed to investigate the differences in lymphocyte function and BNST-cortex circuit FC among three groups.
Results: Our results revealed significant abnormalities in both the BNST-cortex circuit FC and lymphocyte function in PDD patients, with a correlation observed with HAMD scores.
Impact: These findings provide valuable insights into the neurobiological mechanisms of PDD and hold important clinical implications for the early identification of depression in Parkinson's disease patients.
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