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Abstract #4529

Abnormalities in the BNST-Cortex Circuit and Lymphocyte Function in Parkinson's Disease with Depression: An fMRI and DTI-ALPS Study

Yue Zhang1, Bo Liu1, Kan Deng2, and Peng Wu3
1Radiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China, 2Radiology, Bayer Healthcare, Guangzhou, China, 3Philips Healthcare, Shanghai, China

Synopsis

Keywords: Parkinson's Disease, Diffusion Acquisition, DTI-ALPS

Motivation: The pathophysiological mechanisms underlying Parkinson's disease with depression (PDD) remain unclear.

Goal(s): To investigate the differences in lymphocyte function and BNST-cortex circuit functional connectivity(FC) across three groups: PDD, PDND and HC.

Approach: DTI-ALPS metrics and seed-based FC were extracted and statistical analysis was performed to investigate the differences in lymphocyte function and BNST-cortex circuit FC among three groups.

Results: Our results revealed significant abnormalities in both the BNST-cortex circuit FC and lymphocyte function in PDD patients, with a correlation observed with HAMD scores.

Impact: These findings provide valuable insights into the neurobiological mechanisms of PDD and hold important clinical implications for the early identification of depression in Parkinson's disease patients.

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