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Abstract #4530

LRRK2 mutation contributes to decreased free water in the nucleus basalis of Meynert in manifest and premanifest Parkinson’s disease

Chao Wang1, Shuyue Wang1, Cheng Zhou1, and Peiyu Huang1
1Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

Synopsis

Keywords: Parkinson's Disease, Parkinson's Disease

Motivation: Brain cholinergic function has not been investigated to date in LRRK2 mutation carriers with or without PD using free-water imaging.

Goal(s): To investigate the effect of LRRK2 mutations on the cholinergic system in manifest and premanifest stages of PD using free-water imaging.

Approach: We evaluated the effect of LRRK2 mutations on the cholinergic nuclei (i.e., Ch123, Ch4, and pedunculopontine nucleus) in manifest and premanifest stages of PD using free-water imaging.

Results: LRRK2 mutation is associated with decreased free-water content in the Ch4 (also referred to as nucleus basalis of Meynert, nbM).

Impact: This finding suggests early and sustained attempts to compensate for LRRK2-related dysfunction. Free-water imaging has the potential to be applied as a non-radiative imaging technique to identify asymptomatic LRRK2 mutation carriers.

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