Keywords: Parkinson's Disease, Genetics, Restless Legs Syndrome, Parkinson's disease,QSM, Iron, Neuromelanin, polygenic risk scores
Motivation: Restless legs syndrome (RLS) is a sensorimotor disorder that can occur in association with Parkinson’s disease (PD). Our understanding of genetic determinants of MRI-derived nigral iron leading to RLS and PD is limited.
Goal(s): We investigated genetic underpinnings of brain iron imbalance to elucidate the underlying neurodegeneration mechanisms.
Approach: We used quantitative susceptibility mapping and R2* in 3T MRI to obtain regional nigral iron. We obtained polygenic risk scores associated with RLS and iron metabolism disorders.
Results: PD patients without RLS exhibited increased longitudinal nigral iron levels.
Our observations indicated an association between genetic predisposition and elevated nigral iron levels.
Impact: This study demonstrated that PD patients without RLS symptoms exhibit increased longitudinal nigral iron levels, which are correlated with the neuromelanin depigmentation. Our observations indicated an association between genetic predisposition and elevated MRI-derived nigral iron levels.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords