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Abstract #4534

Removing Open-Ended Fringe Lines Facilitates Brain Phase-Based Electrical Properties Tomography in Parkinson’s Disease

Oriana V. Arsenov1, Jierong Luo1, George E. C. Thomas2, Rimona S. Weil2, and Karin Shmueli1
1Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 2Dementia Research Centre, Institute of Neurology, University College London, London, United Kingdom

Synopsis

Keywords: Parkinson's Disease, Artifacts, Electrical Properties Tomography, Phase-based EPT, MR-EPT, Electrical Conductivity

Motivation: Electrical properties tomography (EPT) could have clinical applications, providing useful information in Parkinson’s disease (PD) and other neurodegenerative diseases.

Goal(s): To investigate brain conductivity changes in a PD study.

Approach: Phased-based EPT was applied in 8 PD patients and 8 healthy controls (HC). Regional tissue conductivity values were compared.
To reduce the effects on EPT of open-ended fringe lines in the phase, we investigated a method based on removing affected brain areas.

Results: Removing areas affected by open-ended fringe line reduced artifacts in EPT reconstructions. Cerebral white matter showed significantly lower conductivity in PD relative to HCs.

Impact: Phase-based EPT was calculated in a Parkinson’s disease study by removing areas affected by open-ended fringe lines. We showed that conductivity mapping is feasible even when open-ended fringe lines are present, which will facilitate clinical applications of EPT.

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