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Abstract #4541

Implications of habitat analysis for substantia nigra based on diffusion kurtosis imaging in Parkinson's disease

Ninggui Zhang1, Song'an Shang1, Jie Shi2, Hongying Zhang1, and Jing Ye1
1Northern Jiangsu People’s Hospital, Yangzhou University, China, JiangSu, China, 2GE Healthcare, MR Research, Beijing, China, Beijing, China

Synopsis

Keywords: Parkinson's Disease, Parkinson's Disease

Motivation: Substantia nigra (SN), a core pathological nucleus of Parkinson's disease (PD), exhibits microstructural heterogeneity that remains poorly characterized.

Goal(s): Evaluate the heterogeneity of microstructural changes in the SN using diffusion kurtosis imaging (DKI)-based habitat analysis and assess the diagnostic utility of habitat-derived features in PD.

Approach: 113 PD patients and 110 healthy controls with DKI were analyzed. Habitat fractions and their diagnostic performance were assessed using machine learning models.

Results: PD patients demonstrated heterogeneous changes in SN microstructure reflected by the difference in the fraction of habitats and the robust diagnostic efficacy.

Impact: This study verified habitat analysis based on DKI can subdivide the SN from the aspect of microstructure to further analyze the heterogenetic pathology.

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