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Abstract #4542

Association between Brain Metabolite Changes and Glymphatic Dysfunction in Parkinson’s Disease: A Combined MRS and DTI-ALPS Study

Yun Jung Bae1, Jong Min Kim2, Hye Bin Yoo3, Yilguk Seo4, and Hyeong Hun Lee4
1Radiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea, Republic of, 2Neuroloy, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea, Republic of, 3Institute for Data Innovation in Science, Seoul National University, Seoul, Korea, Republic of, 4METLiT Inc., Seoul, Korea, Republic of

Synopsis

Keywords: Parkinson's Disease, biomarkers, Diffusion Analysis & Visualization, Metabolism, Neuroinflammation, Spectroscopy, Glymphatic system

Motivation: Parkinson's disease (PD) has been linked to impaired glymphatic function, affecting brain waste clearance. However, the interplay between glymphatic function and specific metabolite changes in PD is not well understood.

Goal(s): This study aims to elucidate the relationship between glymphatic dysfunction and metabolic changes in PD and isolated REM sleep behavior disorder (iRBD), a potential precursor to PD.

Approach: We assessed the glymphatic function using the ALPS-index from DTI-ALPS and quantified metabolite ratios in PD and iRBD patients with 3T MRS.

Results: We found significant correlations between ALPS-index and key metabolites, suggesting an association between glymphatic dysfunction, neurotransmitter imbalances, and neuroinflammation in PD.

Impact: Our findings reveal that glymphatic dysfunction in PD may underlie metabolic disruptions, potentially serving as markers for neurodegenerative process. These insights could open new avenues for metabolic and glymphatic-based diagnostic and therapeutic strategies in neurodegenerative diseases.

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