Abstract #4543

Correlation Between Choroid Plexus Calcification and Motor Outcomes of Deep Brain Stimulation in Parkinson’s Disease

Siyuan Fang¹, Gaiying Li¹, Ying Tang¹, Chunhui Yang², Luguang Chen¹, Chao Ma³, Xi Wu², and Jianqi Li¹

¹Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai, China, ²Department of Neurosurgery, Changhai Hospital, Shanghai, China, ³Department of Radiology, Changhai Hospital, Shanghai, China

Synopsis

Keywords: Parkinson's Disease, Parkinson's Disease, choroid plexus, quantitative susceptibility mapping,deep brain stimulation

Motivation: The current clinical predictive factors do not reliably predict DBS outcomes. We hypothesized that the extent of the choroid plexus (ChP) calcification may serve as a potential biomarker for understanding variability in DBS results.

Goal(s): To investigate the relationship between ChP calcification and post-DBS motor outcomes.

Approach: T1-weighted imaging and QSM were performed in forty PD patients who underwent STN-DBS at a 3T MRI system. The relationship between ChP mean susceptibility, calcification volume, and DBS-related motor improvement was evaluated.

Results: ChP calcification relative volume was negatively correlated with total motor improvement, gait stability improvement, and bradykinesia improvement.

Impact: The extent of choroid plexus calcification measured by quantitative susceptibility mapping is negatively correlated with DBS outcomes, offering a potential biomarker to optimize patient-specific DBS prognosis.

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