Abstract #4558

Quantitative IV Contrast-Enhanced MRI Measures Blood-to-CSF Exchange in the Human Brain over 24 Hours

Briana P Meyer¹, Lori Ray², Taylor Pedersen¹, Jacob Reusch¹, Dawn Kernagis³, Jeffery Illif^4,5, and Swati Rane Levendovszky¹

¹Radiology, University of Washington, Seattle, WA, United States, ²Montana State University, Bozeman, MT, United States, ³University of North Carolina, Chapel Hill, NC, United States, ⁴Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, United States, ⁵3. VA Puget Sound Health Care System, Seattle, WA, United States

Synopsis

Keywords: Neurofluids, Neurofluids

Motivation: Previous studies have used intravenous contrast MRI to detect leakage into cerebral spinal fluid (CSF) spaces, yet more research is needed to establish the ideal timing and methodology.

Goal(s): We aimed to determine the optimal time and MRI modalities for detecting contrast leakage into the CSF.

Approach: Hourly scan sessions included quantitative T₁ mapping, heavily T₂w inversion recovery, and/or black blood (BB) sequences over a 24-hour period after contrast in healthy adults.

Results: Contrast was detectable in CSF spaces on T₁ mapping and within 1 hour, persisting for several hours. Possible leakage routes were identified with hT₂W and black-blood (BB) imaging.

Impact: Intravenous contrast leakage into CSF spaces was measured with quantitative and qualitative MRI, advancing methods to assess blood-to-CSF exchange. Contrast appeared within 1 hour and persisted for several hours, with potential leakage routes identified.

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