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Abstract #4561

A Unique Perfusion-Mechanics Relationship in the Hippocampus

Caitlin M. Neher1, Em Triolo1, Oleksandr Khegai2, Priti Balchandani2, and Mehmet Kurt1
1University of Washington, Seattle, WA, United States, 2Icahn School of Medicine at Mount Sinai, New York, NY, United States

Synopsis

Keywords: Neurofluids, Elastography, Arterial Spin Labeling, Hippocampus, Perfusion

Motivation: The hippocampus is a highly scrutinized brain structure due to its implication in many neurological diseases and its vulnerability to insults.

Goal(s): The present study aims to assess the metabolic health and stiffness of the hippocampus in a young cohort, and validate mechanical and metabolic quantities across sequences and magnet strengths.

Approach: 17 subjects (aged 22-35, 7M/10F) were scanned using MR elastography and arterial spin labeling acquisitions at 3T and 7T MRI field strengths.

Results: We observed a strong perfusion-mechanics relationship in the hippocampus across both 3T and 7T subject groups, as well as a highly significant correlation overall, with R=0.70 and p=0.0018.

Impact: Given that the hippocampus is exceptionally vulnerable, with perfusion deficits often seen in diseases related to learning and memory, our results suggest a mechanistic link between metabolic health and stiffness biomarkers in this key region for the first time.

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Keywords