Keywords: Neurofluids, Neurofluids, drowsiness, brain physiological oscillations
Motivation: Low-frequency oscillations (LFOs) dominate grey matter and increase with drowsiness, but their variations across key neurofluid compartments (e.g., arteries and venous sinuses) remain poorly understood.
Goal(s): To investigate how drowsiness influences physiological oscillations across neurofluid compartments.
Approach: Power density in fMRI signals was analyzed across three frequency bands (LFOs, respiration, cardiac pulsation) in five compartments: cerebral arteries, superior sagittal sinus, fourth ventricle CSF, grey and white matter. Changes from alert to drowsiness states were analyzed.
Results: LFO power was highest in grey and white matter, lowest in arteries. Drowsiness led to a global LFO power increase across all compartments, while cardiac power decreased.
Impact: These findings demonstrate regional variability in LFO across neurofluid compartments and reveal a consistent increase during drowsiness, suggesting its potential role in driving glymphatic movement, particularly in sleep.
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