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Abstract #4562

Impact of Drowsiness on Low-Frequency, Respiratory, and Cardiac Oscillations across Neurofluid Compartments

Vidhya V Nair1, Adam M Wright1,2, Tianyin Xu2, Elodie Foster1, Xiaopeng Zhou3, Yunjie Tong2, and Qiuting Wen1,2
1Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, 2Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States, 3School of Health Sciences, Purdue University, West Lafayette, IN, United States

Synopsis

Keywords: Neurofluids, Neurofluids, drowsiness, brain physiological oscillations

Motivation: Low-frequency oscillations (LFOs) dominate grey matter and increase with drowsiness, but their variations across key neurofluid compartments (e.g., arteries and venous sinuses) remain poorly understood.

Goal(s): To investigate how drowsiness influences physiological oscillations across neurofluid compartments.

Approach: Power density in fMRI signals was analyzed across three frequency bands (LFOs, respiration, cardiac pulsation) in five compartments: cerebral arteries, superior sagittal sinus, fourth ventricle CSF, grey and white matter. Changes from alert to drowsiness states were analyzed.

Results: LFO power was highest in grey and white matter, lowest in arteries. Drowsiness led to a global LFO power increase across all compartments, while cardiac power decreased.

Impact: These findings demonstrate regional variability in LFO across neurofluid compartments and reveal a consistent increase during drowsiness, suggesting its potential role in driving glymphatic movement, particularly in sleep.

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Keywords