Keywords: Neurofluids, Perfusion, ASL, normative model
Motivation: Normative modeling offers a powerful way to understand individual differences of brain structure and function by estimating centiles for biological abnormality. Despite its potential, brain perfusion trajectories remain unexplored, limiting insight into structural-functional development and brain diseases.
Goal(s): to map brain perfusion trajectories across the lifespan and identify atypicalities in brain disorders.
Approach: We applied the GAMLSS framework to large multisite ASL data, spanning ages 1 to 85, to model brain perfusion, cerebral blood flow (CBF), across brain regions.
Results: Our normative charts reveal developmental brain perfusion milestones and variations associated with neurological and psychiatric disorders.
Impact: This study introduces lifespan charts for brain perfusion, providing a benchmark for identifying individual deviations across neurological and psychiatric conditions. These charts enable more precise evaluations of CBF atypicalities than previously possible, advancing the understanding brain function in individual level.
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