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Abstract #4572

Choroid plexus and perivascular space enlargement in Alzheimer's disease: a 7T MRI study

Weiwei Zhang1, Haokun Liu2, Long Qian3, Dongcui Wang1, Lu Shen2, and Weihua Liao1,4
1Department of Radiology, Xiangya Hospital of Central South University, Changsha, China, 2Department of Neurology, Xiangya Hospital, Central South University, Changsha, China, 3MR Research Collaboration, MR Research Collaboration, Siemens Healthineers, Guangzhou, China, 4National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, China

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease, 7T MRI

Motivation: Glymphatic dysfunction is implicated in Alzheimer’s disease (AD) through the accumulation of neurotoxic substances.

Goal(s): This study aims to investigate the association between choroid plexus volume (CPV), perivascular spaces (PVS), and cognitive function in AD using 7T MRI.

Approach: Using ultra-high-field 7T MRI, we performed segmentation and volume measurements of PVS and CPV in AD patients and healthy controls, analyzing their relationship with cognitive scores.

Results: The study identified a significant enlargement of PVS in AD, and though not statistically significant, an association between enlarged CPV and reduced cognitive scores was observed.

Impact: This study suggests that CPV and enlarged PVS may serve as new non-invasive MRI marker for glymphatic dysfunction in AD.

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