Keywords: Alzheimer's Disease, Alzheimer's Disease, 7T MRI
Motivation: Glymphatic dysfunction is implicated in Alzheimer’s disease (AD) through the accumulation of neurotoxic substances.
Goal(s): This study aims to investigate the association between choroid plexus volume (CPV), perivascular spaces (PVS), and cognitive function in AD using 7T MRI.
Approach: Using ultra-high-field 7T MRI, we performed segmentation and volume measurements of PVS and CPV in AD patients and healthy controls, analyzing their relationship with cognitive scores.
Results: The study identified a significant enlargement of PVS in AD, and though not statistically significant, an association between enlarged CPV and reduced cognitive scores was observed.
Impact: This study suggests that CPV and enlarged PVS may serve as new non-invasive MRI marker for glymphatic dysfunction in AD.
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