Abstract #4573

Longitudinal cerebral blood flow reduction associated with fast cognitive decline in elderly adults at an individual level

Tianrui Zhao^1,2, Steven Cen^3,4, Jianing Tang^1,2, Sang Hun Chung¹, Elizabeth Joe⁴, Vasilis Marmarelis⁵, Helena Chui⁴, and Lirong Yan^1,2

¹Radiology, Northwestern University, Chicago, IL, United States, ²Biomedical Engineering, Northwestern University, Evanston, IL, United States, ³Radiology, University of Southern California, Los Angeles, CA, United States, ⁴Neurology, University of Southern California, Los Angeles, CA, United States, ⁵Biomedical Engineering, University of Southern California, Los Angeles, CA, United States

Synopsis

Keywords: Alzheimer's Disease, Diagnosis/Prediction

Motivation: Developing and validating an imaging biomarker at an individual level could help improve precision medicine for clinical diagnosis and treatment of neurodegenerative diseases. Cerebral blood flow (CBF) has been revealed as an important biomarker for Alzheimer’s disease (AD). However, the temporal correlation between CBF and cognitive function is rarely reported at an individual level.

Goal(s): To investigate the relationship of longitudinal CBF changes with corresponding temporal changes in cognitive functions.

Approach: Generalized estimating equations (GEE) was used for the repeated measure correlation between region-specific CBF and cognitive functions.

Results: A faster longitudinal CBF reduction is strongly associated with worsened temporal cognitive functions.

Impact: This study fills the gap of research in the association between longitudinal changes of CBF and cognitive functions at an individual level.

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