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Abstract #4574

Linking Brain Reserve to Glymphatic system Function in Mild Cognitive Impairment: Evidenced by Choroid Plexus Volume and DTI-ALPS

zhou liang1, Liu yang1, Yang WenXia1, Zhou YanHu1, Zhen Yu1, Ge Xing1, Ai Kai2, Liu GuangYao1,3, and Zhang Jing1,3
1Department of Magnetic Resonance, The Second Hospital & Clinical Medical School, Lanzhou university, lanzhou, China, 2Philips Healthcare, Xi'an, China, 3Gansu Province Clinical Research Center for Functional and Molecular Imaging, Lanzhou University Second Hospital, lanzhou, China

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease

Motivation: Mild cognitive impairment (MCI) patients are often accompanied with gray matter (GM) atrophy and glymphatic impairment, which are associated with cognition

Goal(s): To explored how glymphatic function is associated with cortical atrophy and cognitive decline in MCI

Approach: We used DTI-ALPS and choroid plexus volume to reflect glymphatic markers. The relationships between glymphatic markers and GM volume and cognition were investigated

Results: Our findings revealed that glymphatic markers were significantly lower in MCI, and were associated with GM atrophy and cognition.

Impact: Our findings highlight that MCI patients exhibited decreased glymphatic activity compared to NCs, and glymphatic activity could be used to evaluate brain reserve in MCI, which is further related to cognitive impairment

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