Abstract #4580

Impact of Sleep on Extracellular Space in Human Brains: A Simultaneous Study with Sodium MRI and EEG

Kennedy Watson^1,2, Xingye Chen^1,2,3, Ying-Chia Lin^1,2, Nahbila-Malikha Kumbella¹, Justin Quimbo¹, Simon Henin⁴, Zena Rockowitz⁵, Anli Liu⁴, Arjun Masurkar⁵, James Babb^1,2, Yulin Ge^1,2, Yvonne Lui^1,2, and Yongxian Qian^1,2

¹Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ²Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ³Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, NY, United States, ⁴Comprehensive Epilepsy Center, Department of Neurology, New York University Grossman School of Medicine, New York, NY, United States, ⁵Alzheimer's Disease Research Center, Department of Neurology, New York University Grossman School of Medicine, New York, NY, United States

Synopsis

Keywords: Aging, Neuro, Sodium MRI, EEG, Sleep

Motivation: The accumulation of amyloid-beta (Aβ) plaques is a key factor in Alzheimer’s Disease pathogenesis. Animal studies indicate that reduced cerebrospinal fluid (CSF) clearance may impair the removal of these neurotoxic proteins by 40-70%, while sleep can double clearance efficiency due to an increase in extracellular space.

Goal(s): To determine the impact of sleep on extracellular space in humans.

Approach: We investigated changes in extracellular volume fraction (ECVF) across sleep stages using simultaneous sodium MRI and electroencephalography (EEG).

Results: A significant decrease in ECVF was observed in gray matter regions of the brain during non-rapid eye movement (NREM) stage 3 sleep.

Impact: Our findings confirmed the impact of sleep on extracellular volume fraction in the human brain, which may influence cerebrospinal fluid clearance and has potential implications for Alzheimer's Disease progression.

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