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Abstract #4584

The coupling of global brain activity and cerebrospinal fluid flow as a potential predictive marker of amyloid-β accumulation

Yuya Tanaka1,2, Koji Kamagata1, Yuya Saito1, Kaito Takabayashi1, Rinako Iseki1, Wataru Uchida1, Christina Andica1,3, Akifumi Hagiwara1, Akihiko Wada1, Toshiaki Akashi1, Osamu Abe2, and Shigeki Aoki1,3
1Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan, 2Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 3Faculty of Health Data Science, Juntendo University, Chiba, Japan

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease, gBOLD-CSF coupling, CSF, clearance, Amyloid β

Motivation: Early identification of individuals at risk for amyloid-β (Aβ) accumulation could enable upstream therapeutic interventions that target clearance dysfunction.

Goal(s): To investigate whether global Blood-Oxygen-Level-Dependent signals (gBOLD) - cerebrospinal fluid (CSF) coupling, a novel indicator of brain clearance function, can identify a future Aβ-positive group in cognitively normal elderly individuals.

Approach: Amyloid converters showed significantly weaker coupling, indicating reduced brain clearance function, with a correlation observed between coupling strength and Aβ accumulation rate.

Results: Amyloid converters showed significantly weaker coupling, indicating reduced brain clearance function, with a correlation observed between coupling strength and Aβ accumulation rate.

Impact: This study clarifies that reduced CSF clearance causes brain Aβ accumulation and demonstrates that gBOLD-CSF coupling could serve as a non-invasive biomarker for predicting future brain Aβ accumulation, potentially enabling pre-preclinical Alzheimer's disease interventions that target clearance dysfunction.

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