Abstract #4635
129Xe red blood cell chemical shift and T2* in patients hospitalised due to COVID-19 with and without residual lung abnormalities seen on CT
Laura Saunders1,2, Guilhem Collier1,2, Graham Norquay1, Laurie Smith1, Paul Hughes1, Scarlett Strikland3,4, Lotta Gustafsson3,4, Thomas Newman4, Megan Plowright4, James Watson4, Zoë Gabriel4, Phillip Wade4, James Meiring3, James T Grist5, Kher Lik Ng5, Arthur Harrison6, James Eaden4, Jody Bray1, Helen Marshall1, David Capener3, Martin Brook1, Alberto Biancardi1, James E Ball1, Neil Stewart1, Kevin M Johnson7, Andy Swift2,3,4, Smitha Rajaram3,4, Lisa Watson4, Paul Collini4, Gary Mills4, Rod Lawson4, Jonathan Brooke6, Phillip Molyneaux8, Amanda Goodwin6, Iain D Stewart8, Ling-Pei Ho5, Joseph Jacob9, Thomas Meersman6, Galina Pavlovskaya6, Fergus Gleeson10,11, Ian Hall6, R Gisli Jenkins12, A. A. Roger Thompson3,4, and Jim Wild1,2
1POLARIS, Division of Clinical Medicine, School of Medicine & Population Health, The University of Sheffield, Sheffield, United Kingdom, 2Insigneo Institute, The University of Sheffield, Sheffield, United Kingdom, 3The University of Sheffield, Sheffield, United Kingdom, 4Sheffield Teaching Hospitals, Sheffield, United Kingdom, 5University of Oxford, Oxford, United Kingdom, 6University of Nottingham, Nottingham, United Kingdom, 7University of Madison, Wisconsin, WI, United States, 8Imperial College London, London, United Kingdom, 9University College London, London, United Kingdom, 10Department of Oncology, University of Oxford, Oxford, United Kingdom, 11Department of Radiology, University of Oxford, Oxford, United Kingdom, 12Margaret Turner Warwick Centre for Fibrosing Lung Disease, National Heart and Lung Institute, Imperial College London, London, United Kingdom
Synopsis
Keywords: Hyperpolarized MR (Gas), Hyperpolarized MR (Gas), long COVID, COVID-19
Motivation: Previous studies show red blood cell (RBC) chemical shift, RBC T2* and M T2* may be sensitive to alveolar-capillary diffusion.
Goal(s): To determine whether these 129Xe MRI measures are associated with markers of clinical function in patients hospitalised due to COVID-19.
Approach: Patients hospitalised due to COVID-19 with and without residual lung abnormalities (RLAs) had 6 month and 1 year MRI. RBC chemical shift, RBC T2* and M T2* were calculated from dissolved phase 129Xe MRI.
Results: RBC chemical shift correlates with TLCO Z-score in patients with RLAs. RBC T2*and M T2* were significantly longer in patients with RLAs, compared to patients without.
Impact: RBC chemical shift is sensitive to alveolar-capillary diffusion abnormalities in patients with residual lung abnormalities following COVID-19 and may enable more sensitive monitoring of gas transfer abnormalities in these patients.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
