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Abstract #4638

129Xe MRI is sensitive to pulmonary hemodynamics in systemic sclerosis patients with suspected pulmonary arterial hypertension

Laura Saunders1,2, Scarlett Strikland3,4, Guilhem Collier1,2, Paul Hughes1, Ian Smith4, Laurie Smith1, Graham Norquay1, Neil Stewart1, Jemima H Pilgrim-Morris1,5, Helen Marshall1, Alberto Biancardi1, Felicity Hitchcock3, Andy Swift2,3,4, Alex Rothman3,4, David Kiely3,4, Robin Condliffe3,4, Jim Wild1,2, and A. A. Roger Thompson3,4
1POLARIS, Division of Clinical Medicine, School of Medicine & Population Health, The University of Sheffield, Sheffield, United Kingdom, 2Insigneo Institute, The University of Sheffield, Sheffield, United Kingdom, 3The University of Sheffield, Sheffield, United Kingdom, 4Sheffield Teaching Hospitals, Sheffield, United Kingdom, 5Insigneo Institute, University of Sheffield, Sheffield, United Kingdom

Synopsis

Keywords: Hyperpolarized MR (Gas), Hyperpolarized MR (Gas), 129Xe, xenon, pulmonary hypertension, systemic sclerosis

Motivation: Early detection of pulmonary arterial hypertension (PAH) can facilitate early treatment, improving outcomes.

Goal(s): To use 1H and 129Xe MR, including 129Xe dissolved phase MRI/MRS, to identify markers of PAH in patients with systemic sclerosis (SSc).

Approach: Patients with SSc and suspected PAH were recruited for 1.5T 1H and 129Xe MRI, and where possible, same day right heart catheterisation and pulmonary function tests.

Results: 13 datasets were analysed. The oscillation amplitude of 129Xe signal dissolved in the red blood cells correlated positively with mean pulmonary artery pressure and is a promising marker of pulmonary hypertension in this population.

Impact: 129Xe red blood cell oscillation amplitude is a promising, non-invasive MRI marker of elevated pulmonary arterial pressure in patients with systemic sclerosis. 1H and 129Xe MRI provide clinically relevant and complementary information on pulmonary function in this population.

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Abstract

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