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Abstract #4645

A Reader Study to Compare Multi-step vs. Standard N4ITK bias field Correction Methods in Xenon MRI

Suphachart Leewiwatwong1, Matthew Willmering2, David Mummy3, Anna Costelle4, Drew Clements3, Hong Qin3, Fuyao Li1, and Bastiaan Driehuys1,3,4
1Biomedical Engineering, Duke University, DURHAM, NC, United States, 2Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 3Radiology, Duke University, DURHAM, NC, United States, 4Medical Physics Graduate Program, Duke University, DURHAM, NC, United States

Synopsis

Keywords: Hyperpolarized MR (Gas), Hyperpolarized MR (Gas)

Motivation: Conducting 129Xe ventilation MRI across different imaging centers requires refined methods of bias field correction to reduce variability between images.

Goal(s): To compare standardized 129Xe MRI ventilation healthy reference values generated with different bias field correction methods using a reader study.

Approach: Six expert readers evaluated 133 subjects (57 healthy from 3 sites) processed with three different healthy reference distributions, including one utilizing multi-step bias field correction. The order of the methods was randomized to ensure blinding.

Results: A multi-step bias field correction demonstrated superior performance with the highest perfect score rates, especially in addressing apical-basal gradient inhomogeneities across sites.

Impact: This study provides valuable insights into the effectiveness of different bias field correction methods in reducing variability and improving quantification accuracy in 129Xe ventilation MRI across multiple imaging centers.

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