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Abstract #4652

Hyperpolarized 1-13C Pyruvate Magnetic Resonance Spectroscopy Distinguishes Hepatocellular Carcinoma Genetic Subgroups In Vivo.

Bukola Yetunde Adebesin1, David Tischfield2, Alexander Zavriyev1, Molly Sheehan2, Ariful Islam2, Vera Shattuck3, Daniel Ackerman2, Steve Kadlecek2, and Terence Gade4
1Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 2Radiology, University of Pennsylvania, Philadelphia, PA, United States, 3Haverford College, Haverford, PA, United States, 4Radiology and Cancer Biology, University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non-Gas), Small animals, MRI, imaging, 13C Spectroscopy, probes, Hepatocellular Carcinoma, HCC, Liver, cancer, amino acids

Motivation: Aberrant activation of the CTNNB1/Wnt pathway is a common molecular alteration in Hepatocellular Carcinoma (HCC) that has been found to impact patients’ response to therapy; however, there is a deficiency of non-invasive biomarkers for stratifying HCC patients based on CTNNB1 mutational status.

Goal(s): We sought to identify a novel non-invasive molecular imaging biomarker of CTNNB1/Wnt pathway mutation in HCCs.

Approach: We assessed metabolic flux in clinically relevant HCC patient-derived xenografts in vivo using Hyperpolarized 1-13C Pyruvate Magnetic Resonance Spectroscopy.

Results: We observed an 86% higher and 14% lower Hyperpolarized 1-13C Pyruvate conversion to Alanine and Lactate respectively in CTNNB1mutant HCCs compared to non-mutants.

Impact: CTNNB1 mutant and non-mutant HCCs can be distinguished non-invasively by assessing Hyperpolarized-1-13C-Pyruvate flux to Alanine and Lactate. Our findings present a promising precision imaging strategy for patient stratification, with the potential to enhance treatment outcomes in HCC and other cancers.

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Keywords