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Abstract #4656

Preliminary results of the utility of Hyperpolarized [1-13C]pyruvate MRI in patients with Autosomal Dominant Polycystic kidney disease.

Malene Aastrup1, Uffe Kjærgaard1, Esben Søvnsø Szocska Hansen1, Nikolaj Bøgh1, Rasmus Hansen2, Charlotte Brinck Holt1,3, Lotte Bonde Bertelsen1, Steffen Ringgard 1, Jens Dam Jensen4, Niels Henrik Buus2, and Christoffer Laustsen1
1Department of clinical medicine, Aarhus University, The MR Research Centre, Aarhus N, Denmark, 2Department of Nephrology, Aarhus University Hospital, Aarhus N, Denmark, 3Aarhus University Hospital, Steno Diabetes Center, Aarhus N, Denmark, 4Department of Nephrology, Aalborg University Hospital, Aalborg, Denmark

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non‐Gas), Multi‐Contrast, kidney, urogenital, cronic kidney disease, autosomal dominant polycystic kidney disease

Motivation: Metabolic features of autosomal-dominant-polycystic-kidney-disease (ADPKD) and chronic kidney disease (CKD) are not fully understood and cannot be examined with current clinical tools. It may be possible with Hyperpolarized [1-13C]pyruvate (HP 13C) MRI.

Goal(s): To evaluate HP 13C MR images including metabolic profiles in both ADPKD- and CKD-patients compared with healthy controls.

Approach: Presenting the preliminary results of initial participants included in the ongoing clinical trial entitled “Chronic kidney disease – imaging the metabolic derangements with ultra-sensitive MRI”.

Results: Initial evaluation of results might indicate metabolic profiles as biomarkers in disease progression in ADPKD patients.

Impact: The metabolic signatures and images obtained from HP 13C MR may help monitoring disease progression in autosomal-dominant-polycystic-kidney-disease (ADPKD) and chronic kidney disease (CKD) and increase knowledge of pathological elements in these diseases.

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