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Abstract #4663

The Influence of Fasting and Anesthesia on Cerebral Metabolism of Hyperpolarized Pyruvate

Thanh Phong Lê1, Andrea Capozzi1,2, Jean-Noël Hyacinthe1, and Mor Mishkovsky1
1Laboratory for Functional and Metabolic Imaging, EPFL, Lausanne, Switzerland, 2Center for Hyperpolarization in Magnetic Resonance (HYPERMAG), Technical University of Denmark (DTU), Lyngby, Denmark

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Brain

Motivation: Fasting is a common procedure to reduce physiological variability and to facilitate surgical procedures. Anesthesia is commonly employed in preclinical research. [1-13C] pyruvate is the gold standard hyperpolarized metabolic contrast agent, since it allows detecting metabolic changes within less than one minute.

Goal(s): Here we aim to investigate how anesthesia and fasting influence cerebral metabolism of hyperpolarized [1-13C]pyruvate.

Approach: Dynamic MRSI at high spatiotemporal resolution characterized HP pyruvate metabolism.

Results: Pyruvate-to-lactate turnover is slower and lower under medetomidine-isoflurane than isoflurane-only anesthesia. Only when mice were anesthetized with medetomidine-isoflurane fasting led to longer decay of the pyruvate signal.

Impact: Fasting and anesthesia influence brain metabolism and consciousness. Higher pyruvate-to-lactate turnover is observed in mice under isoflurane-only than medetomidine-isoflurane anesthesia. Besides the relevance for preclinical studies, this opens opportunities for probing brain biochemistry in anesthetized patients and influence of fasting.

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