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Abstract #4665

Application of diffusion kurtosis imaging for differentiating T0-T1 from T2 rectal tumors

Yu-ru MA1, Shen-ping YU1, Hao-dong QIN2, and Yan CHEN1
1The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, 2MR Research Collaboration, Siemens Healthineers, Guangzhou, China

Synopsis

Keywords: DWI/DTI/DKI, DWI/DTI/DKI, Rectal cancer

Motivation: Accurate MRI-based staging of early rectal tumors is crucial for decision-making in an era of organ-sparing treatment strategies.

Goal(s): To investigate the value of DKI for distinguishing between T0-T1 and T2 rectal tumors.

Approach: 138 patients with pathologically proven T0-T2 rectal tumors were evaluated with HR-T2WI, kurtosis and diffusivity from DKI, and ADC from DWI.

Results: Diffusivity in pT0-T1 rectal tumors was significantly higher compared to pT2 rectal tumors and exhibited the highest diagnostic value in determining pT0-T1 rectal tumors, with an AUC of 0.810, a sensitivity of 70.0%, and a specificity of 82.7%.

Impact: Diffusivity obtained from DKI has the potential to serve as a biomarker for early rectal tumor assessment, providing valuable information for selecting appropriate patients for organ preservation surgery.

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Keywords