Keywords: DWI/DTI/DKI, DWI/DTI/DKI, Rectal cancer
Motivation: Accurate MRI-based staging of early rectal tumors is crucial for decision-making in an era of organ-sparing treatment strategies.
Goal(s): To investigate the value of DKI for distinguishing between T0-T1 and T2 rectal tumors.
Approach: 138 patients with pathologically proven T0-T2 rectal tumors were evaluated with HR-T2WI, kurtosis and diffusivity from DKI, and ADC from DWI.
Results: Diffusivity in pT0-T1 rectal tumors was significantly higher compared to pT2 rectal tumors and exhibited the highest diagnostic value in determining pT0-T1 rectal tumors, with an AUC of 0.810, a sensitivity of 70.0%, and a specificity of 82.7%.
Impact: Diffusivity obtained from DKI has the potential to serve as a biomarker for early rectal tumor assessment, providing valuable information for selecting appropriate patients for organ preservation surgery.
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