Abstract #4691

Quantification of the Thigh Skeletal Muscle Creatine Content in Asymptomatic Individuals and Patients with Knee Osteoarthritis

Yiou Wang¹, Tianzhao Zhong², Xinru Zhang¹, Yueni Chen³, Jialing Chen¹, Ruoxing Liao³, Yanjun Chen¹, Zhongping Zhang⁴, Yin Wu², and Xiaodong Zhang¹

¹Department of Medical Imaging, The Third Affiliated Hospital Southern Medical University, Guangzhou, China, ²Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, ³Southern Medical University, Guangzhou, China, ⁴Philips Healthcare, Guangzhou, China

Synopsis

Keywords: Osteoarthritis, CEST / APT / NOE, Aging

Motivation: Creatine chemical exchange saturation transfer (CrCEST) is a valuable tool to investigate muscle energy metabolism. However, its association with body composition remains unclear.

Goal(s): To investigate the relationship between CrCEST signals with body composition in thigh skeletal muscles of asymptomatic individuals.

Approach: CEST and mDIXON imaging were performed to measure skeletal muscle Cr, fat fraction (FF), and T2* values.

Results: CrCEST exhibited significantly in the right semimembranosus muscle among different gender and body mass index groups. In the right vastus medialis, creatine levels also differed based on exercise intensity. CrCEST in the right biceps femoris exhibited a slight negative correlation with FF values.

Impact: Thigh muscle creatine levels vary among people and are affected by exercise intensity. Lower creatine levels are linked to more muscle fat fraction, indicating a possible link to fat metabolism and energy production, as well as oxidative stress management.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.