Meeting Banner
Abstract #4692

Diffusion Tensor Imaging in Diseased Human Meniscus

Nataliya Tod1, Sarah Salem2, Rui Hu1, Saira Tabassam1, Jie Chen1, Zhuoheng Liu1, Yang Xia2, and Nian Wang1,3,4
1Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, TX, United States, 2Department of Physics, Oakland University, Rochester, MI, United States, 3Department of Biomedical Engineering, The University of Texas Southwestern Medical Center, Dallas, TX, United States, 4Peter O'Donnell Jr. Brain Institute, The University of Texas Southwestern Medical Center, Dallas, TX, United States

Synopsis

Keywords: Osteoarthritis, Tractography

Motivation: Degeneration of the knee meniscus can lead to severe outcomes like osteoarthritis, but early detection can reduce burdens on patients and healthcare systems. Current detection methods are invasive, destructive, or superficial.

Goal(s): We aim to develop a nondestructive technique capable of detecting small changes in whole human menisci.

Approach: Sixteen human menisci at various stages of degradation were imaged and then analyzed using the DTI (diffusion tensor imaging) model.

Results: Severely degraded menisci had more disorganized fiber orientations than moderately degraded ones. Moreover, tissue microstructure showed significant differences between these two groups.

Impact: DTI (diffusion tensor imaging) shows great potential in detecting changes to the microstructure of human menisci at various stages of degeneration. This technique may allow for more precise pathological evaluation and treatment selection for patients suffering from degenerative joint disease.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords