Abstract #4701

Fast Imaging of the Subthalamic Nucleus (STN) at 7T

Se-Hong Oh^1,2, Valentina Zapata-Amaya³, David Escobar³, Stephen Jones², Ken Sakaie², Sean Nagel⁴, and Mark J. Lowe²

¹Department of Biomedical Engineering, Hankuk University, Seoul, Korea, Republic of, ²Diagnostic Radiology, The Cleveland Clinic, Cleveland, OH, United States, ³Department of Biomedical Engineering, The Cleveland Clinic, Cleveland, OH, United States, ⁴Center for Neuro-Restoration, The Cleveland Clinic, Cleveland, OH, United States

Synopsis

Keywords: Parkinson's Disease, Parkinson's Disease

Motivation: To improve outcomes of deep brain stimulation treatment of Parkinson’s Disease (PD) by improving visualization of the subthalamic nucleus (STN) in the presence of motion during MRI.

Goal(s): To evaluate an accelerated gradient recalled echo (aGRE) at 7T.

Approach: In two PD patients, aGRE was compared against conventional GRE and turbo spin echo (TSE) acquisitions. STN delineation was rated by an experienced researcher and a neurosurgeon.

Results: In one subject with low motion, GRE and aGRE image quality was better than that of TSE. In the subject with high motion, GRE was unusable but aGRE and TSE were acceptable.

Impact: Accelerated GRE at 7T offers improved delineation of the STN despite subject motion during MRI. Motion robustness is crucial, as PD patients are prone to movement, and MRI guides lead placement for effective deep brain stimulation treatment.

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