Meeting Banner
Abstract #4706

Automated Segmentation of Neuromelanin and Nigrosome for Parkinson's Disease Diagnostic Assessment

Hwan Heo1, Jeongwon Jo1, MyeongOh Lee1, Intae Shin1, Minseung Kim2, Seokjong Chung3, Sukyun Kang2, and Soohwa Song1
1Heuron, Co.Ltd, Seoul, Korea, Republic of, 2Department of Neurology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea, Republic of, 3Department of Neurology, Yongin Severance Hospital, Yonsei University Health System, Yongin, Korea, Republic of

Synopsis

Keywords: Parkinson's Disease, Parkinson's Disease, Neuromelanin, Nigrosome, Sandwich NM, Standardized uptake value ratio, Parkinson’s Disease

Motivation: Parkinson's disease involves loss of nigrosome and neuromelanin in the substantia nigra, along with iron deposition. We evaluated how combining quantitative markers improves diagnosis accuracy and analyzed correlation between neuromelanin and standardized uptake value ratio (SUVR).

Goal(s): We aimed to evaluate whether combining these quantitative markers could improve diagnostic accuracy and to assess their relationship with SUVR.

Approach: We prospectively collected data to evaluate the diagnostic performance of the model and to assess the correlation with the SUVR.

Results: The combined model achieved an AUC of 0.956 in PD diagnosis, establishing neuromelanin as a useful marker and confirming its significant relationship with SUVR.

Impact: Combining neuromelanin data with nigrosome volume information enhances its utility for disease classification. Neuromelanin demonstrates a meaningful correlation with the standardized uptake value ratio of basal ganglia subregions.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords