Keywords: Parkinson's Disease, Diffusion Analysis and Visualization, Glymphatic system
Motivation: Glymphatic system dysfunction is increasingly linked to neurodegenerative diseases. Assessing glymphatic activity in Parkinson disease (PD), particularly with comorbid anxiety, may provide insights into disease mechanisms and progression.
Goal(s): To quantify glymphatic function using the DTI-ALPS index in PD patients with and without anxiety, compared to healthy controls.
Approach: This study measured ALPS indices in 29 PD patients and 10 healthy controls using 3.0 T MRI with DTI, comparing results between PD with anxiety (PD+A) and PD alone.
Results: ALPS index was lower in PD groups, indicating glymphatic impairment, with no significant difference between PD and PD+A.
Impact: The DTI-ALPS technique shows promise as an imaging biomarker for early diagnosis and monitoring of glymphatic dysfunction in PD, potentially aiding in personalized assessment and management.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords