Abstract #4713

Assessment of interstitial fluid dynamics in patients with idiopathic normal pressure hydrocephalus using spectral diffusion analysis

Shota Ishida^1,2, Shigeki Yamada^3,4, Tatsuya Oki², Shinnosuke Hiratsuka², Mitsuhito Mase³, and Yoshiyuki Watanabe²

¹Department of Radiological Technology, Faculty of medical science, Kyoto College of Medical Science, Kyoto, Japan, ²Department of Radiology, Shiga University of Medical Science, Shiga, Japan, ³Department of Neurosurgery, Nagoya City University Graduate School of Medical Science, Aichi, Japan, ⁴Interfaculty Initiative in Information Studies/Institute of Industrial Science, The University of Tokyo, Tokyo, Japan

Synopsis

Keywords: Neurofluids, Neurofluids, Idiopathic normal pressure hydrocephalus, iNPH, spectral diffusion analysis, IVIM, interstitial fluid

Motivation: Spectral diffusion analysis provides a parameter (F_int) that represents interstitial fluid (ISF) volume.

Goal(s): We aimed to clarify the ISF dynamics in patients with idiopathic normal pressure hydrocephalus (iNPH).

Approach: We compared F_int values between patients with iNPH and healthy controls (HCs) and evaluated the age dependency of F_int.

Results: Significant increases in F_int were observed only in the periventricular hyperintensity (PVH) regions of patients with iNPH, indicating that ISF dynamics may not differ significantly between patients with iNPH and HCs in regions other than the PVH. Additionally, age-dependent changes in ISF volume were observed only in the pons.

Impact: The interstitial fluid (ISF) dynamics between patients with idiopathic normal pressure hydrocephalus and healthy controls may not be significantly different in regions other than the periventricular hyperintensity. Additionally, age-dependent changes in ISF volume were observed only in the pons.

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